BEST/BLS - Bavarian Longitudinal Study Cohort
Four assessments (1985-1990) were carried out daily during the neonatal period, at discharge from hospital, at 5 months and 20 months (corrected for prematurity) and at 56 months of (=4;8 years) chronological age.
Study aims: a) to document the prevalence of somatic and psychosocial outcomes of neonatal problems and early delivery in an unselected population of children in Germany; and b) to evaluate the impact of a regionalised neonatal service to the locally organised service provisions in Germany. For this purpose a geographically defined region in Finland was also studied and the same instruments were used (AYLS).
Phase II (1990-1997)
Two assessments (1991-1993) at 6 and 8 years; Study aims: more intensive investigation of a reduced sample, assessed impact of biological and social risk on cognitive, social and behavioral development and academic achievement, intensive interviewing on parental caretaking and psychopathology.
Phase III (1997-1999)
One assessment (1998-1999) at 13 years (questionnaires were sent out only); Study aims: development of literacy, language and mathematical skills and school achievement, focus on the highest risk group (VP/VLBW) of the original sample only.
Phase IV (2009-2015)
One assessment (2010-2014) at 26 years. Study aims: identification of protective and resiliency factors in the development of children exposed to biological or environmental adversity. The study focused on neuronal, neuro-cognitive and behavioral development, health utility, and quality of life from infancy to adulthood.
- Start Year
- Follow Up Is Ongoing
- Year of Most Recent Data Collection
- New Data Collection planned?
- Supported by grants PKE24, JUG14, 01EP9504, and 01ER0801 from the German Federal Ministry of Education and Science (BMBF), and by grant DFG SCHM 3045/2-1 from the German Research Foundation (DFG)
- Study design
- Number of Data Collection Events
- Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
- Supplementary information about number of participants
Original cohort recruited infants admitted to the NICU in South Bavaria n=7505.
VPT/VLBW subcohort available for RECAP Preterm n=682
1. Riegel K, Ohrt B, Wolke D, K Ö. Die Entwicklung gefährdet geborener Kinder bis zum fünften Lebensjahr: Die Arvo Ylppö-Neugeborenen-Nachfolgestudie in Südbayern und Südﬁnnland [The development of at-risk children until the ﬁfth year of life. The Arvo Ylppö Longitudinal Study in South Bavaria and South Finland] Stuttgart: Ferdinand Enke Verlag; 1995.
2. Schmid G, Schreier A, Meyer R, Wolke D. Predictors of crying, feeding and sleeping problems: a prospective study. Child Care Health Dev 2011;37:493-502.
3. Jaekel J, Baumann N, Wolke D. Effects of Gestational Age at Birth on Cognitive Performance: A Function of Cognitive Workload Demands. Plos One 2013;8.
4. Eryigit-Madzwamuse S, Wolke D. Attention problems in relation to gestational age at birth and smallness for gestational age. Early Hum Dev 2015;91:131-8.
5. Schneider W, Wolke D, Schlagmuller M, Meyer R. Pathsways to school achievement in very preterm and full term children. Eur J Psychol Educ 2004;19:385-406.
6. Eryigit Madzwamuse S, Baumann N, Jaekel J, Bartmann P, Wolke D. Neuro-cognitive performance of very preterm or very low birth weight adults at 26 years. Journal of child psychology and psychiatry, and allied disciplines 2015;56:857-64.
Bavarian Longitudinal Study Cohort
- Geographical Area
- Southern Bavaria
- VPT/VLBW Group Inclusion Criteria
- Infants born during the period February 1985 and March 1986 who required admission to a neonatal unit within the first 10 days after birth, and were born VP/VLBW (<32 weeks gestational age or <1500g birth weight): N=682.
- Control Group Inclusion Criteria
- Healthy infants who were cared for on the normal postnatal wards in the same obstetric hospitals: N=916.
- VPT/VLBW Group Exclusion Criteria
- Control Group Exclusion Criteria
- Supplementary Information
- Data collection of control children started at the same time as for the VP/VLBW infants, beginning at birth and throughout all follow-up assessments.
Data Collection Events
||Perinatal data were collected from medical records and clinical assessments on gestational age, maternal smoking during pregnancy, pregnancy complications, delivery and birth, infant sex, length, ...||1985||1986|
5 Month Follow Up
||At 5 months of age, the participant underwent a neurological and clinical assessment, measurement of length, weight, head circumference, and administration of the Griffiths scale of Babies ...||1985||1987|
20 Month Follow Up
||At 20 months of age, participants underwent a clinical and neurological examination to assess length, weight, head circumference, cerebral palsy, and visual and hearing impairment. The Griffiths ...||1986||1988|
56 Month Follow Up
||At 56 months, participant height, weight and head circumference were measured along with neurological and clinical examination to assess cerebral palsy, and visual and hearing impairment.
6.3 year Follow Up
||At 6 years of age, the participants underwent a clinical neurological assessment, including Test of Motor Impairment (TOMI), Beery VMI, clinical evaluation of cerebral palsy, visual and hearing ...||1991||1993|
8.5 year Follow Up
||At 8 years of age, participants underwent a clinical assessment to assess cerebral palsy, visual and hearing impairment.
Parents of the participant were interviewed about socioeconomic ...
12-13 year Follow Up
||At 12/13 years of age, parents of the participants completed a number of postal questionnaires to collect information on socioeconomic status, living conditions, school reports, bullying, ...||1998||1999|
26 Year Follow Up
||At 26 years of age, participants were interviewed about socioeconomic status, living conditions, life course and bullying. The Munich Composite International Diagnostic Interview (M-CIDI) and ...||2010||2014|