Harmonisation Study / EFGR in very preterm infants

EFGR in very preterm infants - Extreme Fetal Growth Restriction in very preterm infants

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- Describe the prevalence and risk factors of infants with extremely severe fetal growth restriction, using several definitions (weight thresholds, mortality risks, clinical opinion). - Investigate the management and perinatal outcomes (mortality and morbidity) of very preterm infants with EFGR in comparison with other very preterm infants, using these alternative definitions. - Assess the utility of the concept of EFGR for research on VPTI and identify research question related to longer-term outcomes.

Study Design

Cohort study based on pooling data from the RECAP Preterm very preterm cohorts using perinatal data and data up to first discharge home from hospital.

Studies Included


All very preterm (VPT) singleton births (live, stillbirths and terminations, where possible) from 22+0 to 31+6 weeks of gestation with very severe fetal growth restriction; these births will be compared with VPT births with less severe growth restriction and VPT births without growth restriction. We will exclude multiples and infants with severe congenital anomalies (also, if possible, fetal infections such as rubella, CMV).