Individual Study / EPICE-PT

EPICE-PT - Effective Perinatal Intensive Care in Europe - Portugal

Networks -
Datasets -
Variables -



Investigators Contacts
  • Henrique Barros
    Institute of Public Health of the University of Porto
  • Henrique Barros
    Institute of Public Health of the University of Porto


Start Year
Follow Up Is Ongoing
Year of Most Recent Data Collection
New Data Collection planned?
The EPICE-PT cohort received funding from the European Union [EPICE project: Seventh Framework Programme (FP7/2007–2013, No 259882); SHIPS project: Horizon 2020 Research and Innovation Programme, No 633724].


Access to external researchers or third parties provided or foreseen.

Data (questionnaire-derived, measured...)
Other access

Study Design

Study design
Number of Data Collection Events
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
Number of term-born control births included in cohort (live & still births)
Supplementary information about number of participants
974 VPT births were included: 95 terminations of pregnancy; 155 stillbirths; 724 live births (607 infants discharged alive from the hospital). Informed consent for the follow-up evaluations was obtained for 544 infants.

Marker Paper

1. Barros, H., et. al. Effective perinatal intensive care in europe (EPICE): Descrição do Projeto e primeiros resultados em Portugal. Arquivos de Medicina, 28(6), 183-190. 2. Zeitlin J, Maier RF, Cuttini M, Aden U, Boerch K, Gadzinowski J, Jarreau PH, Lebeer J, Norman M, Pedersen P, Petrou S, Pfeil JM, Toome L, van Heijst A, Van Reempts P, Varendi H, Barros H, Draper ES; EPICE and SHIPS Research Group. Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort. Int J Epidemiol. 2020 Apr 1;49(2):372-386. doi: 10.1093/ije/dyz270.

PUBMED 32031620
Additional Publications
  • Rodrigues C, Teixeira R, Fonseca MJ, Zeitlin J, Barros H; Portuguese EPICE (Effective Perinatal Intensive Care in Europe) Network. Prevalence and duration of breast milk feeding in very preterm infants: A 3-year follow-up study and a systematic literature review. Paediatr Perinat Epidemiol. 2018 May;32(3):237-246. doi: 10.1111/ppe.12457.
  • Rodrigues C, Severo M, Zeitlin J, Barros H; Portuguese EPICE (Effective Perinatal Intensive Care in Europe) Network. The Type of Feeding at Discharge of Very Preterm Infants: Neonatal Intensive Care Units Policies and Practices Make a Difference. Breastfeed Med. 2018 Jan/Feb;13(1):50-59. doi: 10.1089/bfm.2017.0135.
  • Costa R, Johnson S, Cuttini M, Pierrat V, Sarrechia I, Barros H, Zeitlin J. The impact of choice of norms on classification of motor impairment for children born very preterm. Early Hum Dev. 2020 Jul;146:105056. doi: 10.1016/j.earlhumdev.2020.105056.
  • Piedvache A, van Buuren S, Barros H, Ribeiro AI, Draper E, Zeitlin J; EPICE Research group. Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age. BMC Med Res Methodol. 2021 Jun 6;21(1):118. doi: 10.1186/s12874-021-01264-3.
  • Seppänen AV, Draper ES, Petrou S, Barros H, Andronis L, Kim SW, Maier RF, Pedersen P, Gadzinowski J, Lebeer J, Ådén U, Toome L, van Heijst AFJ, Cuttini M, Zeitlin J; SHIPS Research Group. Follow-up after very preterm birth in Europe. Arch Dis Child Fetal Neonatal Ed. 2021 Feb 10:fetalneonatal-2020-320823. doi: 10.1136/archdischild-2020-320823.
  • Rodrigues C, Zeitlin J, Wilson E, Toome L, Cuttini M, Maier RF, Pierrat V, Barros H; EPICE Research Group. Managing mother's own milk for very preterm infants in neonatal units in 11 European countries. Acta Paediatr. 2021 Jan;110(1):123-126. doi: 10.1111/apa.15518.
  • Cuttini M, Forcella E, Rodrigues C, Draper ES, Martins AF, Lainé A, Willars J, Hasselager A, Maier RF, Croci I, Bonet M, Zeitlin J. What drives change in neonatal intensive care units? A qualitative study with physicians and nurses in six European countries. Pediatr Res. 2020 Aug;88(2):257-264. doi: 10.1038/s41390-019-0733-9.
  • Lorthe E, Moreira C, Weber T, Huusom LD, Schmidt S, Maier RF, Jarreau PH, Cuttini M, Draper ES, Zeitlin J, Barros H; EPICE research group. Unit policies regarding tocolysis after preterm premature rupture of membranes: association with latency, neonatal and 2-year outcomes (EPICE cohort). Sci Rep. 2020 Jun 12;10(1):9535. doi: 10.1038/s41598-020-65201-y.
  • Seppänen AV, Sauvegrain P, Draper ES, Toome L, El Rafei R, Petrou S, Barros H, Zimmermann LJI, Cuttini M, Zeitlin J; SHIPS Research Group. Parents' ratings of post-discharge healthcare for their children born very preterm and their suggestions for improvement: a European cohort study. Pediatr Res. 2021 Mar;89(4):1004-1012. doi: 10.1038/s41390-020-01120-y.
  • Seppänen AV, Bodeau-Livinec F, Boyle EM, Edstedt-Bonamy AK, Cuttini M, Toome L, Maier RF, Cloet E, Koopman-Esseboom C, Pedersen P, Gadzinowski J, Barros H, Zeitlin J; Effective Perinatal Intensive Care in Europe (EPICE) research group. Specialist health care services use in a European cohort of infants born very preterm. Dev Med Child Neurol. 2019 Jul;61(7):832-839. doi: 10.1111/dmcn.14112.
  • Zeitlin J, Manktelow BN, Piedvache A, Cuttini M, Boyle E, van Heijst A, Gadzinowski J, Van Reempts P, Huusom L, Weber T, Schmidt S, Barros H, Dillalo D, Toome L, Norman M, Blondel B, Bonet M, Draper ES, Maier RF; EPICE Research Group. Use of evidence based practices to improve survival without severe morbidity for very preterm infants: results from the EPICE population based cohort. BMJ. 2016 Jul 5;354:i2976. doi: 10.1136/bmj.i2976.
  • Draper ES, Manktelow BN, Cuttini M, Maier RF, Fenton AC, Van Reempts P, Bonamy AK, Mazela J, Bᴓrch K, Koopman-Esseboom C, Varendi H, Barros H, Zeitlin JJ; EPICE Cohort. Variability in Very Preterm Stillbirth and In-Hospital Mortality Across Europe. Pediatrics. 2017 Apr;139(4):e20161990. doi: 10.1542/peds.2016-1990.
  • El Rafei R, Jarreau PH, Norman M, Maier RF, Barros H, Reempts PV, Pedersen P, Cuttini M, Zeitlin J; EPICE Research Group. Variation in very preterm extrauterine growth in a European multicountry cohort. Arch Dis Child Fetal Neonatal Ed. 2021 May;106(3):316-323. doi: 10.1136/archdischild-2020-319946.
  • Draper ES, Zeitlin J, Manktelow BN, Piedvache A, Cuttini M, Edstedt Bonamy AK, Maier R, Koopman-Esseboom C, Gadzinowski J, Boerch K, van Reempts P, Varendi H, Johnson SJ; EPICE group. EPICE cohort: two-year neurodevelopmental outcomes after very preterm birth. Arch Dis Child Fetal Neonatal Ed. 2020 Jul;105(4):350-356. doi: 10.1136/archdischild-2019-317418.
  • Bonnet C, Blondel B, Piedvache A, Wilson E, Bonamy AE, Gortner L, Rodrigues C, van Heijst A, Draper ES, Cuttini M, Zeitlin J; EPICE Research Group. Low breastfeeding continuation to 6 months for very preterm infants: A European multiregional cohort study. Matern Child Nutr. 2019 Jan;15(1):e12657. doi: 10.1111/mcn.12657.



Selection Criteria
  • Portugal
Geographical Area
Northern Region; Lisbon and Tagus Valley Region.
VPT/VLBW Group Inclusion Criteria
All births (terminations of pregnancy, stillbirths, live births) between 22+0 and 31+6 weeks of gestation. Births occurred between 1st June 2011 and 31st May 2012.
Control Group Inclusion Criteria
VPT/VLBW Group Exclusion Criteria
Control Group Exclusion Criteria
Data Collection Events
# Name Description Start End
0 Perinatal Assessment 2011-06 2012-05
1 1 Year Follow up 2013-01 2013-10
2 2 Year Follow-up 2013-08 2015-04
3 3 Year Follow-up 2014-07 2015-10
4 4 Year Follow-up 2015-10 2016-08
5 5.5 Year Follow-up 2016-09 2018-08
6 7 Year Follow-up 2018-11 2019-08
7 8.5 Year Follow-up 2020-02 2021-05