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Perinatal Assessment
Overview
Data were collected on maternal characteristics, maternal health and obstetric history, pregnancy complications, use of antenatal steroids, labour, delivery, infant characteristics at birth, respiratory support, neonatal morbidity, selected neonatal procedures and medical treatments, neonatal outcomes such as survival, timing of death or discharge from neonatal unit, and follow on care.
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Type of Data Collection Event
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Perinatal
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Supplementary Information
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Index only assessed control group recruited later at 6 years.
4004 births, 306 long term survivors.
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Start Date
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1995
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End Date
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1995
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Data sources
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Questionnaires
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Physical measures
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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0
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Corrected Age
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VPT/VLBW Group |
Control Group |
| Survived |
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| Invited |
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| Assessed |
4004
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Perinatal Information
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VPT/VLBW Group |
Control Group |
| Total Births |
4004
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| Terminations of Pregnancy |
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| Still Births |
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| Live Births |
|
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| Admitted to NICU |
812
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| Survived to Discharge |
315
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Data were collected on maternal characteristics, maternal health and obstetric history, pregnancy complications, use of antenatal steroids, labour, delivery, infant characteristics at birth, ... |
1995 |
1995 |
| 1 |
2.5 Year Follow Up
Overview
At 2.5 years of corrected age, parents of the participant completed a questionnaire on living arrangements, family, socioeconomic status (employment, occupation, education, income), information about the home, childcare arrangements, nursery/playgroup attendance, parental and child handedness, child temperament and behavior, parental health related quality of life, and recent stressful life events
The participant underwent a clinical and neurological examination to assess type and degree of disability (neurological, cerebral palsy, vision, hearing, communication etc). Neurodevelopment was assessed by a trained pediatrician using the Bayley Scales of Infant Development Second Edition (BSID-II) Mental Development Index (MDI) and Psychomotor Development Index (PDI). During the clinical visit the parents were also interviewed about the participant's medical history.
In cases where the infant was not assessed at 2.5 years, the physician of the participant completed a questionnaire about the health and development of the child, based on assessments carried out at around 30 months of age. Data were collected on hospital admissions, anthropometric measurements, neuromotor development, vision, hearing, respiratory health, feeding and nutrition, overall development. In case of infant death, the lead pediatrician responsible for the infant's care completed a questionnaire about the condition of the infant prior to death, and the circumstances of the infant's death.
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Supplementary Information
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No control group (recruited at 6 years).
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Start Date
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1998
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End Date
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1999
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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2
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VPT/VLBW Group |
Control Group |
| Survived |
309
|
|
| Invited |
|
|
| Assessed |
283
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|
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At 2.5 years of corrected age, parents of the participant completed a questionnaire on living arrangements, family, socioeconomic status (employment, occupation, education, income), information ... |
1998 |
1999 |
| 2 |
6 Year Follow Up
Overview
At 6 years of age, participants underwent a clinical examination and neuropsychological assessment. General cognitive ability and academic achievement was assessed using the Kaufman Assessment Battery for Children (KABC). The NEPSY Developmental Neuropsychological test was used to assess sensorimotor function, attention and executive function, and visuospatial processing. Participants also underwent a neurological examination to assess neurological impairment, vision and hearing impairment, communication problems, respiratory problems, other impairments and anthropometric measurements (height, weight, head circumference and mid arm circumference).
Parents of the participant completed a questionnaire about the child to assess child health, respiratory health, long term illness, medications, hearing, vision, speech, hospital admissions, health and social service use, handedness, feeding problems, sleep, childcare and school. Parents also completed a questionnaire about the family including living arrangements, residence, home environment, parental education level, parental employment, work absence due to the participant's health problems, welfare benefits received, additional costs incurred due to the child's health problems, maternal health and health related quality of life, impact of participant's health on other children, and family relationships. To assess child behavior, parents and teachers completed the Strengths and Difficulties Questionnaire (SDQ), and additional items to assess ADHD. The behavior of the participant was evaluated by the assessor at the end of the neurodevelopmental assessment using the Tester Rating of Child Behavior (TRCB). Teachers also provided details of academic achievement.
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Supplementary Information
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Controls recruited at 6 years by Controls were recruited at the 6 year follow-up by identifying classmates of index children in mainstream school who were born at term (37+0 or more weeks of gestation). Controls were invited to participate in the subsequent assessment at 11 years
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Start Date
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2001
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End Date
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2002
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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6
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VPT/VLBW Group |
Control Group |
| Survived |
309
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| Invited |
|
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| Assessed |
241
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160
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At 6 years of age, participants underwent a clinical examination and neuropsychological assessment. General cognitive ability and academic achievement was assessed using the Kaufman Assessment ... |
2001 |
2002 |
| 3 |
11 Year Follow Up
Overview
At 11 years of age, the participants underwent a clinical examination to assess growth (height, weight, occipito-frontal circumference), lung function (respiratory medical history, clinical examination, spirometry), blood pressure, neurological examination, assessment of disability, and the NEPSY Developmental Neuropsychological test was administered to assess executive function, visuospatial processing and sensorimotor function. Buccal swabs were obtained and Genomic DNA extracted for analysis of genetic polymorphisms.
Cognitive function was measured using the Kaufman Assessment Battery for Children (KABC). The Weschler Individual Academic Achievement Test (WIAT-II) as used to measure academic achievement and teachers completed the Teacher Academic Attainment Scale (TAAS). Child behavior was measured using the Strengths and Difficulties Questionnaire (SDQ). Psychiatric problems were assessed using the Development and Well Being Assessment (DAWBA), Social Communication Questionnaire (SCQ) and Du Paul ADHD Rating Scale-IV.
Functional health status was assessed using the Health Utilities Index (HUI-3). Questionnaires also provided information on the child's health and abilities, impact of disability, and health and educational resources utilised by the participant. Socioeconomic status and family structure were assessed for new control children and those whose circumstances have changed since assessment at 6 years.
In cases where the family preferred their child not to undergo the assessment, permission was requested to contact their General Practitioner and school to obtain information to assess the level of any disability.
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Supplementary Information
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Controls were born at term (≥37+0 weeks of gestation). 110 controls were recruited at the 6 year follow-up by identifying classmates of index children in mainstream schools. These controls were invited to participate in the subsequent assessment at 11 years. A further 43 new controls were recruited using the same procedure at the 11 year follow up.
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Start Date
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2005
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End Date
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2007
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Biosamples
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Data sources - Biosamples
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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11
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VPT/VLBW Group |
Control Group |
| Survived |
307
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| Invited |
|
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| Assessed |
219
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153
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At 11 years of age, the participants underwent a clinical examination to assess growth (height, weight, occipito-frontal circumference), lung function (respiratory medical history, clinical ... |
2005 |
2007 |
| 4 |
19 Year Follow Up
Overview
At 19 years of age, participants underwent a clinical examination including anthropometric measurements (height, weight, seated height, head waist and hip circumference), hand grip strength, Modified Incremental Shuttle Walk Test and details of medication. Cardiovascular function was assessed using blood pressure measurements, radial artery waveform analysis and pulse wave velocity, stroke volume and cardiac output measured by NICOM, and ambulatory blood pressure. Respiratory function was assessed using Forced Expiratory NO Analysis and spirometry (pre- and post-bronchodilator). Participants also took part in an overnight sleep study including measurement of respiration during sleep. A neurological examination was performed including classification of cerebral palsy using the Gross Motor Function Classification System (GMFCS) and Manual Ability Classification System (MACS). MRI (3D T1-weighted MPRAGE) was performed to examine white matter, amygdala and thalamic volumes. Ophthalmological assessments were carried out including Best Corrected Visual Acuity (BCVA), anterior segment examinations, dilated posterior segment examinations, assessment of their refractive status, ocular motility and SD OCT imaging. Biosamples were collected for analysis (fasting blood, saliva, urine and sputum collection).
Parents of the participant completed a questionnaire on socioeconomic status (parental employment, education, marital status), the participant's health, effects of participant's health on the family's ability to work, welfare benefits received, parental health and mental health. Parents also completed the Strengths and Difficulties Questionnaire (SDQ) and an adaption of the Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A) to assess participant behavior, and the Health Utilities Index (HUI) to assess health status.
Participants completed a health questionnaire including health and disability, use of alcohol, tobacco and drugs, the HUI to assess health status, and Edinburgh Handedness Inventory (EHI). Additional questions were asked on eating, education and training, employment, marital status, relationships with partner, family and friends. Participants also completed the Quality of Life Scale (QOLS, Burckhardt & Anderson, 2003), satisfaction with Life Scale (SWLS), Rosenberg Self-Esteem Scale, ASEBA Adult Self-Report (ASR), BRIEF-A, empathy quotient (EQ), Broad Autism Phenotype Questionnaire (BAPQ), Pain Catastrophising Scale (PCS), 11-item Big Five Inventory (BFI-11),Warwick-Edinburgh Mental Well-Being Scale (WEMWBS). ADHD was assessed using a translation of the Bavarian Longitudinal Study (BLS) ADHD questionnaire that was adapted from Kooij et al, 2003 and DuPaul ADHD Rating Scale-IV, 1998.
Full scale IQ was measured using Weschler Abbreviated Scale of Intelligence Second Edition (WASI-II), and participants also completed the Beery-Buktenica Test of Visual Motor Integration, Verbal Fluency Task, Attentional Network Test, Automated Working Memory assessment (AWMA), Digit Span, Test of Word Reading Efficiency (TOWRE), Numerical Representation, Woodcock-Johnson III Test of Achievement (WJIII) Math skills - Math Fluency and Calculation (Mathematics) subtests, Frankfurt Test and Training of Facial Affect Recognition (FEFA-2), and Prospective Memory Test.
Participants underwent a Life course interview, Clinical interview Schedule-Revised (CIS-R) semi-structured interview to assess psychiatric symptoms, and Psychosis-Like Symptoms interview (PLIKS). The assessment team rated the participant's behavior according to the Tester's Rating of Adult Behavior (TRAB), and the participant's communication and language skills using the Experimenter Rating of Speech and Language.
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Supplementary Information
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Controls were recruited at the 6 year follow-up by identifying classmates of index children in mainstream school who were born at term (37+0 or more weeks of gestation). Controls were used in subsequent assessments.
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Start Date
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2014
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End Date
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2015
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Biosamples
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Data sources - Biosamples
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Blood
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Urine
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Saliva
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Others : Sputum
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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19
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VPT/VLBW Group |
Control Group |
| Survived |
306
|
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| Invited |
|
|
| Assessed |
129
|
65
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At 19 years of age, participants underwent a clinical examination including anthropometric measurements (height, weight, seated height, head waist and hip circumference), hand grip strength, ... |
2014 |
2015 |