Individual Study / EPICure

EPICure - EPICure


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The aim of the EPICure Study is to determine survival rates and long term health, developmental, educational and psychological outcomes across the lifespan following birth at 25 weeks of gestation or less in the whole of the UK and Ireland in 1995. Index babies were identified at birth and parental consent was sought for follow-up post-hospital discharge.

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Investigators Contacts
  • Neil Marlow
    University College London
  • Dr Yanyan Ni
    University College London

Overview

Acronym
EPICure
Start Year
1995
Follow Up Is Ongoing
Year of Most Recent Data Collection
2015
New Data Collection planned?
Uncertain

Access

Access to external researchers or third parties neither provided nor foreseen.

Study Design

Study design
Cohort
Number of Data Collection Events
5
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
4004
Supplementary information about number of participants
306 long term survivors

Marker Paper

Costeloe K, Hennessy E, Gibson AT, Marlow N, Wilkinson AR. The EPICure study: outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics. 2000;106:659-71.

Two year data:
Wood NS, Marlow N, Costeloe K, et al. Neurologic and developmental disability after extremely preterm birth. New England Journal of Medicine 2000;343(6):378-84. doi: 10.1056/NEJM200008103430601

PUBMED 11015506

Timeline

Population

All extremely preterm births at or before 25 weeks of gestation in all 276 maternity units in the whole of the UK and Ireland from 1st March 1995 to 31st December 1995.
Selection Criteria
Countries
  • United Kingdom
  • Ireland
Geographical Area
All of United Kingdom and Repulic of Ireland
VPT/VLBW Group Inclusion Criteria
Birth at or before 25+6 weeks of gestation.
Control Group Inclusion Criteria
Controls were recruited at the 6 year follow-up by identifying classmates of index children in mainstream school who were born at term (37+0 or more weeks of gestation). Controls were used in subsequent assessments.
VPT/VLBW Group Exclusion Criteria
none
Control Group Exclusion Criteria
Birth before 37+0 weeks gestational age.
Supplementary Information
Control group included for 6, 11, 19 year follow up. Where possible the same control child was used at 6 and 11 year follow ups, if not a new child was selected.
Data Collection Events
# Name Description Start End
0 Perinatal Assessment Data were collected on maternal characteristics, maternal health and obstetric history, pregnancy complications, use of antenatal steroids, labour, delivery, infant characteristics at birth, ... 1995 1995
1 2.5 Year Follow Up At 2.5 years of corrected age, parents of the participant completed a questionnaire on living arrangements, family, socioeconomic status (employment, occupation, education, income), information ... 1998 1999
2 6 Year Follow Up At 6 years of age, participants underwent a clinical examination and neuropsychological assessment. General cognitive ability and academic achievement was assessed using the Kaufman Assessment ... 2001 2002
3 11 Year Follow Up At 11 years of age, the participants underwent a clinical examination to assess growth (height, weight, occipito-frontal circumference), lung function (respiratory medical history, clinical ... 2005 2007
4 19 Year Follow Up At 19 years of age, participants underwent a clinical examination including anthropometric measurements (height, weight, seated height, head waist and hip circumference), hand grip strength, ... 2014 2015