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EPICure 2 - EPICure 2

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EPICure 2 is a population study of health and development after birth before 27 weeks of gestation during 2006. Evaluations were carried out at discharge (Clinical Data), at 3 years and we have just completed an 11-12year follow up. The latter assessment was carried out with classmate controls.

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Investigators	Contacts
Neil Marlow University College London Neil Marlow Name Neil Marlow Email n.marlow@ucl.ac.uk Phone +44 2076790834 Institution University College London Department Neonatology Address 343, Medical School Building, 74 Huntley St London United Kingdom

Overview

Acronym: EPICure 2
Start Year: 2006
Follow Up Is Ongoing
Year of Most Recent Data Collection: 2018
New Data Collection planned?: No

Access

Access to external researchers or third parties neither provided nor foreseen.

Study Design

Study design: Cohort
Number of Data Collection Events: 3
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births): 3133

Marker Paper

Perinatal:
Costeloe KL, Hennessy EM, Haider S, Stacey F, Marlow N, Draper ES. Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies). BMJ. 2012;345:e7976.
3 year follow up:
Moore T, Hennessy EM, Myles J, Johnson SJ, Draper ES, Costeloe KL, Marlow N. Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies. BMJ. 2012;345:e7961.

PUBMED 23212881

Timeline

Population

Population based cohort, following up all births between 22 and 26 weeks of gestation in maternity units in England to mothers who were usually resident in England.

Selection Criteria

Countries

United Kingdom

Geographical Area

All of England

VPT/VLBW Group Inclusion Criteria

All births in England between 22 and 26 completed weeks of gestation.

Control Group Inclusion Criteria

Controls were recruited at the 11 year follow-up by identifying classmates of index children in mainstream school who were born at term (37+0 or more weeks of gestation).

VPT/VLBW Group Exclusion Criteria

none

Control Group Exclusion Criteria

Birth before 37 weeks of gestation.

Supplementary Information

Control group included at 11 year follow up.

Data Collection Events

Name

Description

Start

End

Perinatal Assessment

Overview

Data were collected on maternal socioeconomic and demographic characteristics, maternal health and obstetric history, pregnancy course, pregnancy complications, use of antenatal steroids, tocolysis, labour, delivery, infant condition at birth, respiratory support, neonatal morbidity, congenital anomalies, selected neonatal procedures and medical treatments, neonatal nutrition, decisions to withdraw or withhold treatment, neonatal outcomes such as survival, timing of death or discharge from neonatal unit.

In addition a Unit profile study was undertaken to collect data about unit activity, staffing and policies within neonatal units in 2005. Data on policies in associated maternity units was also collected.

Start Date: 2006
End Date: 2006

Data sources

Questionnaires
Physical measures

Participants

Age at Data Collection Event (years): 0

	VPT/VLBW Group	Control Group
Survived
Invited
Assessed	3133

Data were collected on maternal socioeconomic and demographic characteristics, maternal health and obstetric history, pregnancy course, pregnancy complications, use of antenatal steroids, ...

2006

3 Year Follow Up

Overview

At 2 years of age (24 months), a postal questionnaire was sent to parents of the participants to collect data on the participant's health, feeding, development, contacts with the health service and other developmental or educational professionals. The M-CHAT was also used to screen for autism and the PARCA-R questionnaire to assess cognitive and language development.

At 3 years of age (30 months), participants underwent a clinical assessment to measure height, weight, head circumference, upper arm circumference, and blood pressure. Neurological and respiratory examinations (as in EPICure1 at 2.5 years) were also performed. Gross Motor Function Classification System (GMFCS) was used to assess motor functional impairment. The Bayley-III Cognitive and Language Scales, and BSID-II Mental Development Index were also administered by the assessor.

The parents were sent a questionnaire to collect health service utilisation, sociodemographic and socio-emotional data. In addition, the parents completed the Brief Infant Toddler Social Emotional Assessment (BITSEA).

Supplementary Information: Full cohort assessed. No control group was available at 3 years (control group recruited at 6 year data collection).
Start Date: 2008
End Date: 2010

Data sources

Questionnaires
Cognitive measures
Physical measures

Participants

Age at Data Collection Event (years): 3

	VPT/VLBW Group	Control Group
Survived	1031
Invited	1031
Assessed	584

At 2 years of age (24 months), a postal questionnaire was sent to parents of the participants to collect data on the participant's health, feeding, development, contacts with the health service ...

2008

2010

11 Year Follow Up

Overview

At 11 years of age, participants were invited to take part in a school-based assessment by a clinician and psychologist. Participants underwent a clinical examination including growth measures (height, weight, head circumference), lung function (spirometry), blood pressure and Doppler studies. Cognitive ability (IQ) was measured using the Kaufman Assessment Battery for Children Second Edition (KABC-II). Neuropsychological skills were assessed using the NEPSY-II Developmental Neuropsychological test, and visuo-spatial working memory was assessed using the Weschler Intelligence Scale for Children (WISC-V) Working Memory Index. Academic attainment was assessed using the Weschler Individual Achievement Test (WIAT-II; Reading and Mathematics scales). Teachers also completed an assessment of the participant's learning attainment and national attainment test results were obtained.

Mental health and behavior were assessed using the Development and Well-Being Assessment (DAWBA), Strengths and Difficulties Questionnaire (SDQ), ADHD Rating Scale-V and Social Communication Questionnaire (SCQ). Health-Related Quality of Life was assessed using the Health Utilities Index (HUI-3).

Supplementary Information: Controls were recruited at the 11 year follow-up by identifying classmates of index children in mainstream school who were born at term (37+0 or more weeks of gestation).
Start Date: 2017
End Date: 2018

Data sources

Questionnaires
Cognitive measures
Physical measures

Participants

Age at Data Collection Event (years): 11

	VPT/VLBW Group	Control Group
Survived
Invited
Assessed

At 11 years of age, participants were invited to take part in a school-based assessment by a clinician and psychologist. Participants underwent a clinical examination including growth measures ...

2017

2018

Individual Study / EPICure 2

EPICure 2 - EPICure 2

Members

Overview

Access

Study Design

Marker Paper

Timeline

Population

Selection Criteria

Files

Data Collection Events

Files

Variables Classifications

Individual Study / EPICure 2

EPICure 2 - EPICure 2

Members

Neil Marlow

Overview

Access

Study Design

Marker Paper

Timeline

Population

Selection Criteria

Files

Data Collection Events

Perinatal Assessment

Overview

Participants

3 Year Follow Up

Overview

Participants

11 Year Follow Up

Overview

Participants

Files

Variables Classifications