Individual Study / EPICure 2

EPICure 2 - EPICure 2

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EPICure 2 is a population study of health and development after birth before 27 weeks of gestation during 2006. Evaluations were carried out at discharge (Clinical Data), at 3 years and we have just completed an 11-12year follow up. The latter assessment was carried out with classmate controls.

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Investigators Contacts
  • Neil Marlow
    University College London


EPICure 2
Start Year
Follow Up Is Ongoing
Year of Most Recent Data Collection
New Data Collection planned?


Access to external researchers or third parties neither provided nor foreseen.

Study Design

Study design
Number of Data Collection Events
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)

Marker Paper

Costeloe KL, Hennessy EM, Haider S, Stacey F, Marlow N, Draper ES. Short term outcomes after extreme preterm birth in England: comparison of two birth cohorts in 1995 and 2006 (the EPICure studies). BMJ. 2012;345:e7976.
3 year follow up:
Moore T, Hennessy EM, Myles J, Johnson SJ, Draper ES, Costeloe KL, Marlow N. Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies. BMJ. 2012;345:e7961.

PUBMED 23212881



Population based cohort, following up all births between 22 and 26 weeks of gestation in maternity units in England to mothers who were usually resident in England.
Selection Criteria
  • United Kingdom
Geographical Area
All of England
VPT/VLBW Group Inclusion Criteria
All births in England between 22 and 26 completed weeks of gestation.
Control Group Inclusion Criteria
Controls were recruited at the 11 year follow-up by identifying classmates of index children in mainstream school who were born at term (37+0 or more weeks of gestation).
VPT/VLBW Group Exclusion Criteria
Control Group Exclusion Criteria
Birth before 37 weeks of gestation.
Supplementary Information
Control group included at 11 year follow up.
Data Collection Events
# Name Description Start End
0 Perinatal Assessment Data were collected on maternal socioeconomic and demographic characteristics, maternal health and obstetric history, pregnancy course, pregnancy complications, use of antenatal steroids, ... 2006 2006
1 3 Year Follow Up At 2 years of age (24 months), a postal questionnaire was sent to parents of the participants to collect data on the participant's health, feeding, development, contacts with the health service ... 2008 2010
2 11 Year Follow Up At 11 years of age, participants were invited to take part in a school-based assessment by a clinician and psychologist. Participants underwent a clinical examination including growth measures ... 2017 2018