Individual Study / EPIPAGE 1

EPIPAGE 1 - Étude épidémiologique sur les petits âges gestationnels

Networks -
Datasets -
Variables -


Investigators Contacts
  • Pierre-Yves Ancel
    INSERM UMR 1153
  • Pierre-Yves Ancel
    INSERM UMR 1153
  • Laetitia Marchand-Martin
    INSERM UMR 1153


Start Year
End Year
Follow Up Is Ongoing
Year of Most Recent Data Collection
New Data Collection planned?


Access to external researchers or third parties provided or foreseen.

Data (questionnaire-derived, measured...)
Other access

Study Design

Study design
Number of Data Collection Events
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
Supplementary information about number of participants

Marker Paper

1. Survival of very preterm infants: Epipage, a population based cohort study. Larroque B, Bréart G, Kaminski M, Dehan M, André M, Burguet A, Grandjean H, Ledésert B, Lévêque C, Maillard F, Matis J, Rozé JC, Truffert P; Epipage stusy group. Arch Dis Child Fetal Neonatal Ed. 2004 Mar;89(2):F139-44.
2. Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study. Larroque B, Ancel PY, Marret S, Marchand L, André M, Arnaud C, Pierrat V, Rozé JC, Messer J, Thiriez G, Burguet A, Picaud JC, Bréart G, Kaminski M; EPIPAGE Study group. Lancet. 2008 Mar 8;371(9615):813-20. doi: 10.1016/S0140-6736(08)60380-3.
3. Special care and school difficulties in 8-year-old very preterm children: the Epipage cohort study. Larroque B, Ancel PY, Marchand-Martin L, Cambonie G, Fresson J, Pierrat V, Rozé JC, Marpeau L, Thiriez G, Alberge C, Bréart G, Kaminski M, Marret S; Epipage Study group. PLoS One. 2011;6(7):e21361. doi: 10.1371/journal.pone.0021361. Epub 2011 Jul 8.


EPIPAGE 1 Cohort

Selection Criteria
  • France
Geographical Area
Alsace, Franche-Comté, Languedoc-Roussillon, Lorraine, Midi-Pyrénées, Pays de la Loire, Haute Normandie, Nord-Pas-de-Calais, Paris and its immediate suburbs (9 regions).
VPT/VLBW Group Inclusion Criteria
All infants live born or stillborn and all terminations of pregnancy between 22 and 32 completed weeks of gestation (recruited between January 1 and December 31, 1997)
a sample of moderate preterm births (births and terminations of pregnancy) born between 33 and 34 completed weeks (2 month recruitment - april and october, 1997)
A sample of infants live born between 22 and 26 weeks of gestation, in 8 of the 9 regions between January 1 and December 31, 1998.
Control Group Inclusion Criteria
Infants born alive between 39 and 40 completed weeks (one week recruitment in 1997).
VPT/VLBW Group Exclusion Criteria
Control Group Exclusion Criteria
Data Collection Events
# Name Description Start End
0 Perinatal Assessment 1997 1998
1 2 Months After discharge 1997 1998
2 9 Month Follow Up 1997 1999
3 1 Year Follow up 1998 1999
4 2 Year Follow Up 1999 2000
5 3 Year Follow Up 2000 2001
6 4 Year Follow Up 2001 2002
7 5 Year Follow Up 2002 2003
8 8 Year Follow Up 2006 2006