Individual Study / EPIPAGE 1

EPIPAGE 1 - Étude épidémiologique sur les petits âges gestationnels


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Datasets -
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The EPIPAGE 1 study aimed to assess the outcome of very preterm (VPT) babies, to identify early predictors of health problems and developmental disorders, and to assess the impact of the organization of perinatal care and management during childhood.

Members

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Investigators Contacts
  • Pierre-Yves Ancel
    INSERM UMR 1153
  • Pierre-Yves Ancel
    INSERM UMR 1153
  • Laetitia Marchand-Martin
    INSERM UMR 1153

Overview

Acronym
EPIPAGE 1
Start Year
1997
End Year
2005
Follow Up Is Ongoing
Year of Most Recent Data Collection
2006
New Data Collection planned?
No

Access

Access to external researchers or third parties provided or foreseen.

Data (questionnaire-derived, measured...)
Biosamples
Other access

Study Design

Study design
Cohort
Number of Data Collection Events
9
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
3581
Supplementary information about number of participants

Marker Paper

1. Survival of very preterm infants: Epipage, a population based cohort study. Larroque B, Bréart G, Kaminski M, Dehan M, André M, Burguet A, Grandjean H, Ledésert B, Lévêque C, Maillard F, Matis J, Rozé JC, Truffert P; Epipage stusy group. Arch Dis Child Fetal Neonatal Ed. 2004 Mar;89(2):F139-44.
2. Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study. Larroque B, Ancel PY, Marret S, Marchand L, André M, Arnaud C, Pierrat V, Rozé JC, Messer J, Thiriez G, Burguet A, Picaud JC, Bréart G, Kaminski M; EPIPAGE Study group. Lancet. 2008 Mar 8;371(9615):813-20. doi: 10.1016/S0140-6736(08)60380-3.
3. Special care and school difficulties in 8-year-old very preterm children: the Epipage cohort study. Larroque B, Ancel PY, Marchand-Martin L, Cambonie G, Fresson J, Pierrat V, Rozé JC, Marpeau L, Thiriez G, Alberge C, Bréart G, Kaminski M, Marret S; Epipage Study group. PLoS One. 2011;6(7):e21361. doi: 10.1371/journal.pone.0021361. Epub 2011 Jul 8.

Timeline

Population

Population based cohort consisting of all births (live births, still births and termination of pregnancy) in all maternity units in the 9 regions.
Selection Criteria
Countries
  • France
Geographical Area
Alsace, Franche-Comté, Languedoc-Roussillon, Lorraine, Midi-Pyrénées, Pays de la Loire, Haute Normandie, Nord-Pas-de-Calais, Paris and its immediate suburbs (9 regions).
VPT/VLBW Group Inclusion Criteria
All infants live born or stillborn and all terminations of pregnancy between 22 and 32 completed weeks of gestation (recruited between January 1 and December 31, 1997)
+
a sample of moderate preterm births (births and terminations of pregnancy) born between 33 and 34 completed weeks (2 month recruitment - april and october, 1997)
+
A sample of infants live born between 22 and 26 weeks of gestation, in 8 of the 9 regions between January 1 and December 31, 1998.
Control Group Inclusion Criteria
Infants born alive between 39 and 40 completed weeks (one week recruitment in 1997).
VPT/VLBW Group Exclusion Criteria
none
Control Group Exclusion Criteria
none
Data Collection Events
# Name Description Start End
0 Perinatal Assessment Data on pregnancy, delivery and care prior to transfer to the neonatal unit were collected from maternal obstetric records and the obstetric team. This included data on pregnancy, multiples, ... 1997 1998
1 2 Months After discharge Two months after returning home from the hospital, the mother completed a questionnaire about their experiences of returning home. Data were collected on childcare arrangements, age at discharge, ... 1997 1998
2 9 Month Follow Up At 9 months of age, questionnaires were sent to the mother and father of the participant to assess the health and development of the infant, history of hospital admissions and contact with medical ... 1997 1999
3 1 Year Follow up At 12 months, a short questionnaire was sent to the parents of participants to investigate the growth, health, medication usage, hospital admissions, sleep, nutrition and neurodevelopment of the ... 1998 1999
4 2 Year Follow Up At 2 years of age, the mother of the participant completed a questionnaire on childcare and living arrangements, feeding and nutrition, sleep, behavior, history of hospital admissions and visits ... 1999 2000
5 3 Year Follow Up At 3 years of age, parents of the participant completed a questionnaire about living and childcare arrangements, anthropometric measurements (height, weight, head circumference), health and ... 2000 2001
6 4 Year Follow Up At 4 years of age, the parents of the participant completed a questionnaire on living arrangements, anthropometric measurements (height, weight, head circumference), general health, respiratory ... 2001 2002
7 5 Year Follow Up At 5 years of age, the parents of the participant completed a questionnaire about school, childcare arrangements, sleep, diet, and parent-child activities performed. Details of health and ... 2002 2003
8 8 Year Follow Up At 8 years of age, parents of the participants completed a questionnaire to assess anthropometric measurements (height, weight, head circumference), health, vision, hearing, language and speech ... 2006 2006