Individual Study / EPIPAGE 2

EPIPAGE 2 - Étude épidémiologique sur les petits âges gestationnels

EPIPAGE 2 logo
Networks -
Datasets -
Variables -



Investigators Contacts
  • Pierre-Yves Ancel
    INSERM UMR 1153
  • Laetitia Marchand-Martin
    INSERM UMR 1153
  • valerie benhammou
    Inserm UMR1153
  • Anass Rtimi
    Inserm UMR 1153


Start Year
Follow Up Is Ongoing
Year of Most Recent Data Collection
New Data Collection planned?
National Research Agency


Access to external researchers or third parties provided or foreseen.

Data (questionnaire-derived, measured...)
Other access

Supplementary Information

Study Design

Study design
Number of Data Collection Events
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
Supplementary information about number of participants
5 170 liveborn infants included at birth in the cohort

Marker Paper

1. EPIPAGE 2: a preterm birth cohort in France in 2011. Ancel PY, Goffinet F; EPIPAGE 2 Writing Group. BMC Pediatr. 2014 Apr 9;14:97. doi: 10.1186/1471-2431-14-97.
2. Survival and morbidity of preterm children born at 22 through 34 weeks' gestation in France in 2011: results of the EPIPAGE-2 cohort study. Ancel PY, Goffinet F; EPIPAGE-2 Writing Group. JAMA Pediatr. 2015 Mar;169(3):230-8. doi: 10.1001/jamapediatrics.2014.3351.
3. Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks' gestation in France in 2011: EPIPAGE-2 cohort study. Pierrat V, Marchand-Martin L, Arnaud C, Kaminski M, Resche-Rigon M, Lebeaux C, Bodeau-Livinec F, Morgan AS, Goffinet F, Marret S, Ancel PY; and the EPIPAGE-2 writing group. BMJ. 2017 Aug 16;358:j3448. doi: 10.1136/bmj.j3448.


EPIPAGE 2 Cohort

Selection Criteria
  • France
Geographical Area
25 regions: 21 of the 22 metropolitan regions, and 4 overseas regions of France.
Alsace, Aquitaine, Auvergne, Basse-Normandie, Bretagne, Bourgogne, Centre-Val de Loire, Champagne-Ardenne, Corse, Franche-Comté, Haute-Normandie, Île-de-France, Languedoc-Roussillon, Limousin, Lorraine, Midi-Pyrénées, Nord-Pas-de-Calais, PACA, Pays de la Loire, Picardie, Rhône-Alpes, Guyane, Martinique, La Réunion, and Guadeloupe.
VPT/VLBW Group Inclusion Criteria
All infants (live born, stillborn) and all terminations of pregnancy between 22 and 31 completed weeks of gestation
a sample of moderate preterm births (all births and late terminations) at 32–34 weeks. Recruitment between March 28, 2011 and December 31, 2011.
Control Group Inclusion Criteria
Controls groups could be selected from the Elfe study, a contemporary French cohort with a 20-year planned follow-up of 18 500 children born at or near term in 2011, in 344 randomly selected public and private maternity units in metropolitan France (
600 infants born at term (>=37 weeks) are recruited from the Elfe study as a control group at the 5 and a half year follow up.
VPT/VLBW Group Exclusion Criteria
Control Group Exclusion Criteria
Data Collection Events
# Name Description Start End
0 Perinatal Assessment 2011-03 2011-12
1 1 Year Follow up 2012-04 2013-03
2 2 Year Follow Up 2013-04 2014-03
3 5.5 Year Follow Up 2016-09 2017-12