Individual Study / EPIPAGE 2

EPIPAGE 2 - Étude épidémiologique sur les petits âges gestationnels


EPIPAGE 2 logo
Networks -
Datasets -
Variables -

The EPIPAGE 2 study aims: 1. to describe short- and long-term outcomes in very and moderately preterm babies and their families; 2. to study changes in medical practices and organization of care and assess their impact on child health and development; 3. to explore the etiology of preterm birth and identify early predictors of health and developmental problems.

Visit EPIPAGE 2

Members

Download
Investigators Contacts
  • Pierre-Yves Ancel
    INSERM UMR 1153
  • Laetitia Marchand-Martin
    INSERM UMR 1153
  • valerie benhammou
    Inserm UMR1153
  • Anass Rtimi
    Inserm UMR 1153

Overview

Acronym
EPIPAGE 2
Start Year
2011
Follow Up Is Ongoing
Year of Most Recent Data Collection
2017
New Data Collection planned?
Yes
Funding
National Research Agency

Access

Access to external researchers or third parties provided or foreseen.

Data (questionnaire-derived, measured...)
Biosamples
Other access

Supplementary Information

Study Design

Study design
Cohort
Number of Data Collection Events
4
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
5170
Supplementary information about number of participants
5 170 liveborn infants included at birth in the cohort

Marker Paper

1. EPIPAGE 2: a preterm birth cohort in France in 2011. Ancel PY, Goffinet F; EPIPAGE 2 Writing Group. BMC Pediatr. 2014 Apr 9;14:97. doi: 10.1186/1471-2431-14-97.
2. Survival and morbidity of preterm children born at 22 through 34 weeks' gestation in France in 2011: results of the EPIPAGE-2 cohort study. Ancel PY, Goffinet F; EPIPAGE-2 Writing Group. JAMA Pediatr. 2015 Mar;169(3):230-8. doi: 10.1001/jamapediatrics.2014.3351.
3. Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks' gestation in France in 2011: EPIPAGE-2 cohort study. Pierrat V, Marchand-Martin L, Arnaud C, Kaminski M, Resche-Rigon M, Lebeaux C, Bodeau-Livinec F, Morgan AS, Goffinet F, Marret S, Ancel PY; and the EPIPAGE-2 writing group. BMJ. 2017 Aug 16;358:j3448. doi: 10.1136/bmj.j3448.

Timeline

Population

Population based cohort - All births (live births, still births and terminations of pregnancy) in maternity units within the regions.
Selection Criteria
Countries
  • France
Geographical Area
25 regions: 21 of the 22 metropolitan regions, and 4 overseas regions of France.
Alsace, Aquitaine, Auvergne, Basse-Normandie, Bretagne, Bourgogne, Centre-Val de Loire, Champagne-Ardenne, Corse, Franche-Comté, Haute-Normandie, Île-de-France, Languedoc-Roussillon, Limousin, Lorraine, Midi-Pyrénées, Nord-Pas-de-Calais, PACA, Pays de la Loire, Picardie, Rhône-Alpes, Guyane, Martinique, La Réunion, and Guadeloupe.
VPT/VLBW Group Inclusion Criteria
All infants (live born, stillborn) and all terminations of pregnancy between 22 and 31 completed weeks of gestation
+
a sample of moderate preterm births (all births and late terminations) at 32–34 weeks. Recruitment between March 28, 2011 and December 31, 2011.
Control Group Inclusion Criteria
Controls groups could be selected from the Elfe study, a contemporary French cohort with a 20-year planned follow-up of 18 500 children born at or near term in 2011, in 344 randomly selected public and private maternity units in metropolitan France (www.elfe-france.fr).
600 infants born at term (>=37 weeks) are recruited from the Elfe study as a control group at the 5 and a half year follow up.
VPT/VLBW Group Exclusion Criteria
none
Control Group Exclusion Criteria
none
Data Collection Events
# Name Description Start End
0 1 Year Follow up At one year of age (corrected age), a questionnaire was sent to the parents to investigate the participant's anthropometric measurements (height, weight, head circumference), hospital admissions ... 2012-04 2013-03
1 Perinatal Assessment Data about pregnancy and birth were extracted from medical records or obtained by questionnaires sent to the maternity unit including maternal SES and demographic characteristics, maternal and ... 2011-03 2011-12
2 2 Year Follow Up At 2 years of age (corrected age) the parents of the participant completed a questionnaire on anthropometric measurements (height, weight, head circumference), use of aids and equipment, hospital ... 2013-04 2014-03
3 5.5 Year Follow Up At 5 years of age, participants underwent a clinical and psychological examination, and parents completed questionnaires. A clinical assessment was performed by a physician including evaluation of ... 2016-09 2017-12