Individual Study / NTNU LBW Life

NTNU LBW Life - NTNU Low Birth Weight in a Lifetime Perspective Study


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The NTNU Low Birth Weight in a Lifetime Perspective Study (NTNU LBW Life) comprises a group of preterm, very low birth weight (VLBW; ≤1500g) infants, a group of term born small for gestational age (SGA; bw <10th centile) infants and a group of term born controls, all born 1986-1988 in Mid-Norway. Participants have been examined at several time points throughout childhood, adolescence and into adulthood. The overall aim of the project is to study long-term consequences of low birth weight in a lifetime perspective with focus on somatic and mental health, cognitive and motor function, quality of life, vision and cerebral MRI.

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Investigators Contacts
  • Assoc. Prof Kari Risnes
    Norwegian University of Science and Technology (NTNU)
  • Prof. Marit Sæbø Indredavik
    NTNU
  • Prof. em. Ann-Mari Brubakk
    NTNU
  • Researcher Tora Sund Morken
    NTNU
  • Assoc. prof. Siri Weider
    NTNU
  • Prof. Asta Kristine Håberg
    NTNU
  • Prof. Eero Kajantie
    THL
  • Assoc. Prof Kari Risnes
    Norwegian University of Science and Technology (NTNU)
  • Assoc. Prof Kari Anne I. Evensen
    Norwegian University of Science and Technology (NTNU)

Overview

Acronym
NTNU LBW Life
Start Year
1986
End Year
2029
Follow Up Is Ongoing
Year of Most Recent Data Collection
2014
New Data Collection planned?
Yes
Funding
Norwegian Research Council, The Liaison Committee for Education, Research and Innovation in Central Norway, The Joint Research Committee of St. Olavs hospital and Faculty of Medicine and Health Sciences, NTNU

Access

Access to external researchers or third parties provided or foreseen.

Data (questionnaire-derived, measured...)
Biosamples
Other access

Supplementary Information

Self-, parent-, teacher-report, diagnostic interviews, objective measurements: physical, motor, visual, cognitive and cerebral MRI

Study Design

Study design
Cohort
Number of Data Collection Events
8
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
121
Supplementary information about number of participants
88 infants survived

Marker Paper

Indredavik MS, Vik T, Evensen KAI, Skranes J, Taraldsen G, Brubakk A-M. Perinatal risk and psychiatric outcome in adolescents born preterm with very low birth weight or term small for gestational age. J Dev Behav Pediatr 2010;31(4):286-294.

PUBMED 20431402

Timeline

Population

Single centre cohort, all VLBW infants <1500g admitted to the NICU at St. Olavs Hospital, Trondheim University Hospital.
Control group were all children born to mothers of a 10% random sample in the Trondheim region in the same years as the VLBW group.
Selection Criteria
Countries
  • Norway
Geographical Area
Mid-Norway (Counties of South and North Trøndelag, Møre and Romsdal, City of Trondheim)
VPT/VLBW Group Inclusion Criteria
VLBW: All infants admitted to the NICU at St. Olavs Hospital, Trondheim University Hospital ≤ 1500 g.
Control Group Inclusion Criteria
All babies born at term with weight >10th percentile in the Trondheim region in 1986-1988. A 10% random sample was selected for follow up.
VPT/VLBW Group Exclusion Criteria
Congenital anomalies and syndromes.
Control Group Exclusion Criteria
Congenital anomalies and syndromes.
Data Collection Events
# Name Description Start End
0 Perinatal Assessment Information on perinatal variables was collected retrospectively from hospital records. Data collected around birth included birth weight, gestational age, head circumference, APGAR scores, days ... 1986 1988
1 1 Year Follow up Infants underwent an assessment at 1 year of age to examine anthropometrics, motor and cognitive function and cerebral MRI. A physical assessment was performed including a Neuropediatric ... 1989-04 1990-05
2 5 Year Follow Up At 5 years of age, participants underwent an examination to assess physical health, motor function and neurodevelopment, and quantitative cerebral MRI.

Cognitive development was assessed ...
1992-05 1994-12
3 14 Year Follow Up Assessment at 14 years of age included a neuropsychological assessment, questionnaires and diagnostic interviews for psychiatric disorders, assessment of parents' mental health, physical and motor ... 2000-11 2002-10
4 18 Year Follow Up At 18 years of age, participants completed questionnaires on smoking habits, asthma and medications. A physical and clinical assessment was performed including measurement of height, weight, BMI, ... 2006-02 2006-02
5 19 Year Follow Up At 19-20 years of age, participants underwent a psychiatric diagnostic interview, neuropsychological assessment, quantitative MRI imaging and assessment of socioeconomic status.

...
2006-08 2008-11
6 23 Year Follow Up At 23 years of age, participants underwent physical, neuropsychological and motor assessment, self-report questionnaires and cerebral MRI.

A physical assessment was conducted including ...
2009-02 2009-09
7 26 Year Follow Up Participants were assessed at 26 years and underwent a psychiatric diagnostic interview, neuropsychological assessment, clinical physical assessment and cerebral MRI. Blood samples were taken for ... 2013-06 2014-12