| 0 |
Perinatal Assessment
Overview
Information on perinatal variables was collected retrospectively from hospital records. Data collected around birth included birth weight, gestational age, head circumference, APGAR scores, days in NICU, days on mechanical ventilator, intraventricular hemorrhage (IVH) and maternal age.
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Type of Data Collection Event
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Perinatal
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Supplementary Information
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Data of VLBW cohort retrieved from hospital records retrospectively, thus included all live-born infants in the cohort. Data of control group prospectively collected in a multicenter study.
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Start Date
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1986
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End Date
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1988
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Data sources
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Data sources - Administrative databases
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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0
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Corrected Age
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|
VPT/VLBW Group |
Control Group |
| Survived |
88
|
|
| Invited |
121
|
|
| Assessed |
121
|
120
|
Perinatal Information
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VPT/VLBW Group |
Control Group |
| Total Births |
121
|
120
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| Terminations of Pregnancy |
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|
| Still Births |
|
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| Live Births |
121
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120
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| Admitted to NICU |
121
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4
|
| Survived to Discharge |
88
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120
|
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Information on perinatal variables was collected retrospectively from hospital records. Data collected around birth included birth weight, gestational age, head circumference, APGAR scores, days ... |
1986 |
1988 |
| 1 |
1 Year Follow up
Overview
Infants underwent an assessment at 1 year of age to examine anthropometrics, motor and cognitive function and cerebral MRI. A physical assessment was performed including a Neuropediatric examination (based on Touwen, 1979), measurement of height, weight, head circumference, upper arm circumference, subscapular skinfold thickness. Motor and cognitive skills were examined by use of the Bayley Scales of Infant Development (BSID) - Psychomotor Index and Mental Index. Quantitative MRI (2D T1 weighted inversion recovery, T2 weighted spin echo sequences at 1.5 T) was performed to measure volumes for a number of brain structures.
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Supplementary Information
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Subset Born 1988.
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Start Date
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1989-04
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End Date
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1990-05
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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1
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VPT/VLBW Group |
Control Group |
| Survived |
40
|
|
| Invited |
39
|
|
| Assessed |
31
|
97
|
|
Infants underwent an assessment at 1 year of age to examine anthropometrics, motor and cognitive function and cerebral MRI. A physical assessment was performed including a Neuropediatric ... |
1989-04 |
1990-05 |
| 2 |
5 Year Follow Up
Overview
At 5 years of age, participants underwent an examination to assess physical health, motor function and neurodevelopment, and quantitative cerebral MRI.
Cognitive development was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI). Yale Children's Inventory (YCI) was used to assess attentional deficits and learning difficulties. Physical and motor assessments included a neuropediatric examination (based on Touwen, 1979), anthropometric measurements (height, weight, head circumference, upper arm circumference, triceps and subscapular skinfold thickness). Three subscales from Peabody Developmental Motor Scales were also administered (Eye/hand coordination, balance, and locomotor).
Quantitative MRI was performed to measure volumes for a number of brain structures (2D T1 weighted inversion recovery, T2 weighted spin echo sequences at 1.5 T).
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Supplementary Information
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Subset Born 1988 + 5 born 1987.
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Start Date
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1992-05
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End Date
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1994-12
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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5
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VPT/VLBW Group |
Control Group |
| Survived |
45
|
|
| Invited |
44
|
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| Assessed |
29
|
96
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|
At 5 years of age, participants underwent an examination to assess physical health, motor function and neurodevelopment, and quantitative cerebral MRI.
Cognitive development was assessed ... |
1992-05 |
1994-12 |
| 3 |
14 Year Follow Up
Overview
Assessment at 14 years of age included a neuropsychological assessment, questionnaires and diagnostic interviews for psychiatric disorders, assessment of parents' mental health, physical and motor assessment, ophthalmological assessment, quantitative MRI of cerebral white matter, and assessment of (parental) socioeconomic status.
For the psychiatric assessment, the following instruments were used: The diagnostic interview Schedule for Affective disorders and Schizophrenia for School-Age children - Present and Lifetime Version (K-SADS-PL), Children's Global Assessment Scale (CGAS), Achenbach System of Empirically Based Assessment (ASEBA) - Youth Self Report (YSR), ASEBA Child Behavior Checklist (CBCL) and ASEBA Teacher Report Form (TRF), ADHD Rating scale IV, Autism Spectrum Screening Questionnaire (ASSQ), Strengths and Difficulties Questionnaire (SDQ), Child Health Questionnaire (CHQ) - Child Form (CHQ CF87) & Parent Form (CHQ-PF50) and Parental Bonding Instrument (PBI) - self and parent version.
Parents’ mental health was assessed using Symptom Checklist-90-R (SCL-90-R).
A neuropsychological assessment was performed including Wechsler Intelligence Scale for Children Third Edition (WISC-III; vocabulary, arithmetic, block design, picture arrangement subscales), Trail Making Test (TMT) - A&B, Stroop, Knox Cube, Visual Motor Integration (VMI-IV), Grooved Pegboard, Wisconsin Card Sorting Test (WCST), and Connors' Continuous Performance Test.
Physical and motor assessments conducted included a neuropediatric examination (based on Touwen, 1979), patient reported medical history, measurement of height, weight, BMI, head circumference, pubertal development (Tanner stage), upper arm circumference, triceps and subscapular skinfold thickness, blood pressure and heart rate, Movement Assessment Battery for Children (Movement ABC), Edinburgh Handedness Inventory, Inter- and intra-sensory modality matching (von Hofsten C, Rösblad B. The integration of sensory information in the development of precise manual pointing. Neuropsychologia 1988;26:805-821).
Visual function was assessed using Snellen letter chart at 4 m distance to test visual acuity, Vistech contrast sensitivity chart for near at 40 cm distance to test contrast sensitivity, TNO test (Lameris Ootech BV, Nieuwegein) and Titmus test (Stereo Optical, Chicago IL, USA) to test stereoacuity, Alternating prism cover test at distance and near for strabismus, assessment of all directions of gaze, mono- and binocularly and with magnification during examination in a split lamp to assess nystagmus, and accomodation and convergence were tested using the Royal Air Force (RAF) ruler.
Quantitative MRI was performed to measure volumes for a number of brain structures (3D T1 and T2 weighted spin echo sequences and T1 weighted inversion recovery sequences, Diffusion tensor imaging (DTI) at 1.5 T), MR spectroscopy (1.5T Siemens Symphony).
Parental Socioeconomic status was calculated using Hollingshead Two Factor Index of Social Position (education and occupation).
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Supplementary Information
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Full Cohort assessed.
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Start Date
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2000-11
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End Date
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2002-10
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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14
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VPT/VLBW Group |
Control Group |
| Survived |
88
|
|
| Invited |
86
|
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| Assessed |
69
|
87
|
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Assessment at 14 years of age included a neuropsychological assessment, questionnaires and diagnostic interviews for psychiatric disorders, assessment of parents' mental health, physical and motor ... |
2000-11 |
2002-10 |
| 4 |
18 Year Follow Up
Overview
At 18 years of age, participants completed questionnaires on smoking habits, asthma and medications. A physical and clinical assessment was performed including measurement of height, weight, BMI, head circumference, upper arm circumference, waist and hip circumference, triceps and subscapular skinfold thickness, blood pressure and heart rate.
Lung function was measured using Spirometry, Carbon monoxide transfer factor (TLCO) measured using the “Single breath” method, Static lung volumes and Maximal O2-uptake. Endothelial function was measured via ultrasound (Vivid 7 system GE Vingmed Ultrasound AS).
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Supplementary Information
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Full Cohort assessed.
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Start Date
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2006-02
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End Date
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2006-02
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Data sources
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Questionnaires
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Physical measures
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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18
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VPT/VLBW Group |
Control Group |
| Survived |
88
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| Invited |
84
|
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| Assessed |
46
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76
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At 18 years of age, participants completed questionnaires on smoking habits, asthma and medications. A physical and clinical assessment was performed including measurement of height, weight, BMI, ... |
2006-02 |
2006-02 |
| 5 |
19 Year Follow Up
Overview
At 19-20 years of age, participants underwent a psychiatric diagnostic interview, neuropsychological assessment, quantitative MRI imaging and assessment of socioeconomic status.
Psychiatric disorders were diagnosed via a semi-structured diagnostic interview using the Schedule for Affective Disorders and Schizophrenia for School-Age Children – Present and Lifetime Version (K-SADS-PL) and Children’s Global Assessment Scale (CGAS). This was supplemented with the Achenbach System of Empirically Based Assessment (ASEBA) Adult Self Report (ASR) form, ADHD Rating Scale IV, Autism Spectrum Quotient (AQ), and Self-Perception Profile for Adolescents, Revised (SPPA-R). Health-Related Quality of Life was measured using the Short Form 36 Health Survey (SF-36).
Participants underwent a neuropsychological assessment including Wechsler Adult Intelligence Scale (WAIS-III), Wisconsin Card Sorting Test (WCST), Stroop, Wechsler Memory Scale III (VMS-III), Connors’s Continuous Performance Test (CPT), Visual-Motor Integration (VMI-IV), Grooved Pegboard, Rey Complex Figure Test (RCFT) and Behavior rating inventory of executive function – adult version (BRIEF-A). Selected tests from the Delis-Kaplan Executive Function System (D-KEFS) - Trail Making Test (TMT) 1-5, Verbal Fluency (VF), Design Fluency (DF) were also performed.
Quantitative MRI was performed to measure volumes for a number of brain structures (2D T1 weighted, diffusion tensor imaging (DTI).
Parental Socioeconomic status was calculated using Hollingshead Two Factor Index of Social Position (education and occupation) based on data collected at 14 years.
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Supplementary Information
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Full Cohort assessed.
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Start Date
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2006-08
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End Date
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2008-11
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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19
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VPT/VLBW Group |
Control Group |
| Survived |
88
|
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| Invited |
84
|
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| Assessed |
55
|
80
|
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At 19-20 years of age, participants underwent a psychiatric diagnostic interview, neuropsychological assessment, quantitative MRI imaging and assessment of socioeconomic status.
... |
2006-08 |
2008-11 |
| 6 |
23 Year Follow Up
Overview
At 23 years of age, participants underwent physical, neuropsychological and motor assessment, self-report questionnaires and cerebral MRI.
A physical assessment was conducted including questionnaires on injuries, illness, pain, medications and exercise. The weight, height, BMI and head circumference of the participant were measured. In addition, motor skills were assessed using the Movement Assessment Battery for Children Second Edition (Movement ABC-2), High-Level Mobility Assessment Tool (HiMAT) and Edinburgh Handedness Inventory.
Neuropsychological assessment included Trail Making Test (TMT) 1-5 from the Delis-Kaplan Executive Function System (D-KEFS), Grooved Pegboard and Behavior rating inventory of executive function – adult version (BRIEF-A).
Mental health was assessed using the Achenbach System of Empirically Based Assessment (ASEBA) - Adult Self Report (ASR), and the Beck Depression Inventory (BDI). The Short Form 36 Health Survey (SF-36) was used to measure Health-Related Quality of Life.
Quantitative MRI was also performed to measure volumes for a number of brain structures - 3D T1 (MPRAGE, ADNI sequence), 3D FLAIR (Fluid attenuation inversion recovery), 3D T2, Diffusion tensor imaging (DTI) and fMRI (resting state and attention task).
Parental Socioeconomic status was calculated using Hollingshead Two Factor Index of Social Position (education and occupation) based on data collected at 14 years.
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Supplementary Information
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Subset of Cohort invited.
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Start Date
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2009-02
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End Date
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2009-09
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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23
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VPT/VLBW Group |
Control Group |
| Survived |
88
|
|
| Invited |
54
|
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| Assessed |
36
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37
|
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At 23 years of age, participants underwent physical, neuropsychological and motor assessment, self-report questionnaires and cerebral MRI.
A physical assessment was conducted including ... |
2009-02 |
2009-09 |
| 7 |
26 Year Follow Up
Overview
Participants were assessed at 26 years and underwent a psychiatric diagnostic interview, neuropsychological assessment, clinical physical assessment and cerebral MRI. Blood samples were taken for biochemical and genetic analyses.
A semi-structured interview was performed to carry out a psychiatric diagnostic assessment of the participant using the Mini-International Neuropsychiatric Interview (M.I.N.I. Plus). Global Assessment of Functioning (GAF) was scored by the interviewer. Self-report questionnaires included the Achenbach System of Empirically Based Assessment (ASEBA) - Adult Self Report (ASR), Strengths and Difficulties Questionnaire (SDQ), Adult ADHD Self-Report Scale, Autism Spectrum Quotient (AQ), Peters Delusions Inventory, Rosenberg Self Esteem Scale (RSES) and Fatigue Severity Scale. Health-Related Quality of Life was measured using the Short Form 36 Health Survey (SF-36).
Participants underwent a neuropsychological assessment: two subtests from the Delis-Kaplan Executive Functions system (D-KEFS) - Trail Making Test (TMT) and Verbal Fluency (VF), Wechsler Abbreviated Scale of Intelligence (WASI), Wechsler Memory Scale Third Edition (WMS-III), Grooved Pegboard (GP), and selected tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) - Motor Screening Task (MOT), Big/little Circle (BLC), Paired Associates Learning (PAL), Intra-Extra Dimensional Set Shift (IED), Stockings of Cambridge (SOC), Spatial Working Memory (SWM), Attention Switching Task (AST), Rapid Visual Information Processing (RVP), Emotion Recognition Task (ERT).
A physical and clinical assessment was performed including patient reported medical history, anthropometric measurements (height, weight, BMI, head circumference, upper arm circumference, triceps and subscapular skinfold thickness), blood pressure, heart rate, and dual X-ray absorptiometry (DXA) scan. Questionnaires on physical activity, diet, contraception, pain and sleep were also completed by the participants.
Quantitative MRI was performed to measure volumes for a number of brain structures 3D T1 (MPRAGE, ADNI sequence), 3D FLAIR (Fluid attenuation inversion recovery), 3D T2, Diffusion tensor imaging (DTI).
Fasting blood samples were collected for biochemical and possible genetic analyses. A number of biochemical analyses are available and further processing of the samples is possible for Single Nucleotide Polymorphisms (SNPs) of candidate genes.
Parental Socioeconomic status was calculated using Hollingshead Two Factor Index of Social Position (education and occupation) based on data collected at 14 years.
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Supplementary Information
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Full Cohort assessed.
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Start Date
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2013-06
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End Date
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2014-12
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Data sources
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Questionnaires
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Cognitive measures
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Physical measures
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Biosamples
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Data sources - Biosamples
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Files
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| # |
Name |
Description |
Size |
Actions |
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No files could be found.
Participants
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Age at Data Collection Event (years)
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26
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VPT/VLBW Group |
Control Group |
| Survived |
88
|
|
| Invited |
84
|
|
| Assessed |
64
|
90
|
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Participants were assessed at 26 years and underwent a psychiatric diagnostic interview, neuropsychological assessment, clinical physical assessment and cerebral MRI. Blood samples were taken for ... |
2013-06 |
2014-12 |