PIPARI - Development and Functioning of Very Low Birth Weight Infants from Infancy to School Age
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PIPARI project (Development and Functioning of Very Low Birth Weight Infants from Infancy to School Age) is a multidisciplinary project, where a 6-year cohort of VLBW/VPT infants (born between 1/2001-12/2006) is followed till adulthood in Turku University Central Hospital, Finland. The children have been followed from perinatal period, and currently we are performing follow up at 17 years of age. The multidisciplinary team has been evaluating physical, motor, cognitive, and neuropsychological development of these children. Also psychological well-being of these children and their parents has been evaluated.
Visit PIPARI
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Overview
- Acronym
- PIPARI
- Start Year
- 2001
- Follow Up Is Ongoing
- Year of Most Recent Data Collection
- 2019
- Funding
- The PIPARI study has been funded by: the Finnish Foundation for Alcohol Studies The Arvo and Lea Ylppö Foundation Sundells Stiftelse Emil Aaltonen’s Foundation the Signe and Ane Gyllenberg Foundation Kesko the Finnish Academy of Science the South-West Finnish Fund of Neonatal Research Foundation for Paediatric Research Otto A. Malm Foundation the Päivikki and Sakari Sohlberg Foundation Finnish Cultural Foundation Finnish Association of Pediatric Neurology The National Graduate School of Clinical Investigation The Hospital District of Southwest Finland the Turku University Hospital Research Foundation state funding for university level health research the Finnish Medical Society Duodecim, Turunmaa Duodecim Society Åbo Akademi / Department of Psychology
Access
Access to external researchers or third parties neither provided nor foreseen.
Study Design
- Study design
- Cohort
- Number of Data Collection Events
- 10
- Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
- 255
- Number of term-born control births included in cohort (live & still births)
- 188
- Supplementary information about number of participants
- 255 VPT/VLBW live births.
Marker Paper
Reiman M, Kujari H, Maunu J, Parkkola R, Rikalainen H, Lapinleimu H, Lehtonen L, Haataja L; PIPARI Study Group. Does placental inflammation relate to brain lesions and volume in preterm infants? J Pediatr. 2008 May;152(5):642-7, 647.e1-2. doi: 10.1016/j.jpeds.2007.09.051. Epub 2007 Dec 21.
PUBMED 18410766
- Additional Publications
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- Nyman A, Korhonen T, Munck P, Parkkola R, Lehtonen L, Haataja L. Factors affecting the cognitive profile of 11-year-old children born very preterm. Pediatr Res. 2017 Aug;82(2):324-332. doi: 10.1038/pr.2017.64. Epub 2017 May 24. PMID: 28422947.
Timeline
PIPARI cohort
PIPARI is a regional cohort consisting of infants born in Turku University Hospital between 2001 and 2006 at very low birth weight or very preterm.
Selection Criteria
- Countries
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- Finland
- Geographical Area
- Southwest Finland
- VPT/VLBW Group Inclusion Criteria
- Infants born in Turku university hospital between January 2001 and December 2006. Inclusion criteria were 1) infant’s birth weight ≤1500 grams (VLBW), and after April 2004, infant’s birth weight ≤1500 grams or gestational age below 32 weeks (VPT), 2) infant’s parents spoke and understood written Finnish or Swedish, and 3) families lived inside the hospital catchment area.
- Control Group Inclusion Criteria
- Full term infants born in Turku university hospital between 11/2001 to 12/2003. The parents of first boy and girl born in each week was asked to take part in the study. If they refused, the parents of next boy/girl were asked. Inclusion criteria were 1) birth weight ≥-2 SD according to age and gender specific Finnish growth charts 2) gestational age ≥37 weeks at birth 3) the family lived inside the hospital catchment area 4) the child was not admitted to neonatal care during the first week of life 5) family was Finnish or Swedish speaking.
- VPT/VLBW Group Exclusion Criteria
- Infants with major congenital anomalies or syndromes or chromosomal anomalies were excluded.
- Control Group Exclusion Criteria
- 1) congenital anomalies or syndromes 2) mothers self-reported use of illicit drugs or alcohol during the pregnancy.
- Supplementary Information
- Controls were recruited right after birth before discharge from maternity ward in the beginning of the data collection period. Same group was used at each age.
Data Collection Events
| # | Name | Description | Start | End |
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| 0 |
Perinatal Assessment
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Perinatal data were collected prospectively as part of the PIPARI protocol. Data were collected on maternal characteristics, pregnancy, delivery, neonatal characteristics and early mortality. ... | 2001-01 | 2006-12 |
| 1 |
6 Month Follow Up
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2001 | 2007 | |
| 2 |
1 Year Follow Up
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At one year of corrected age, participants' growth (height, weight and head circumference) was measured by a nurse. Cognitive function was assessed using the Finnish translation of Bayley Scales ... | 2002 | 2007 |
| 3 |
2 Year Follow Up
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Growth measures (weight, height, head circumference) measured by a nurse during routine health checks. A neurological assessment was also carried out on the very preterm group of children using ... | 2003 | 2008 |
| 4 |
3 Year Follow Up
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At 3 years of age, parents of participants completed the Child Behavior Checklist for ages 1.5-5 (CBCL) to assess parent reported child behaviour and emotional Problems. | 2004 | 2009 |
| 5 |
4 Year Follow Up
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At 4 years of chronological age, emotional and behavioural problems were evaluated using the parent-report form of the Child Behavior Checklist 1.5-5 years (CBCL) (n=133). Parents also completed ... | 2005 | 2010 |
| 6 |
5 Year Follow Up
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At 5 years of age, participants completed the short form of the Wechsler Preschool and Primary Scale of Intelligence – Revised (WPPSI-R) including the subtests Information, Sentences, Arithmetic, ... | 2006 | 2011 |
| 7 |
7 Year Follow Up
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At 7 years of age, the reading and mathematics skills of participants were assessed as they were entering primary school. Reading skills were assessed using a letter knowledge task, phoneme ... | 2008 | 2013 |
| 8 |
11 Year Follow Up
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At 11 years of age, a neurological examination of participants was performed using the Touwen examination and examinations were classified together with an experience child neurologist. The ... | 2012 | 2017 |
| 9 |
13 Year Follow Up
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At 12 years of age, child behaviour and mental health was evaluated using the parent form of the Child Behaviour Checklist 6-18 (CBCL). Brain MRI including functional MRI (fMRI) and Diffusion ... | 2014 | 2019 |