Individual Study / PIPARI

PIPARI - Development and Functioning of Very Low Birth Weight Infants from Infancy to School Age

Networks -
Datasets -
Variables -



Investigators Contacts
  • Liisa Lehtonen
    University of Turku
  • Milla Ylijoki
    University of Turku


Start Year
Follow Up Is Ongoing
Year of Most Recent Data Collection
The PIPARI study has been funded by: the Finnish Foundation for Alcohol Studies The Arvo and Lea Ylppö Foundation Sundells Stiftelse Emil Aaltonen’s Foundation the Signe and Ane Gyllenberg Foundation Kesko the Finnish Academy of Science the South-West Finnish Fund of Neonatal Research Foundation for Paediatric Research Otto A. Malm Foundation the Päivikki and Sakari Sohlberg Foundation Finnish Cultural Foundation Finnish Association of Pediatric Neurology The National Graduate School of Clinical Investigation The Hospital District of Southwest Finland the Turku University Hospital Research Foundation state funding for university level health research the Finnish Medical Society Duodecim, Turunmaa Duodecim Society Åbo Akademi / Department of Psychology


Access to external researchers or third parties neither provided nor foreseen.

Study Design

Study design
Number of Data Collection Events
Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
Number of term-born control births included in cohort (live & still births)
Supplementary information about number of participants
255 VPT/VLBW live births.

Marker Paper

Reiman M, Kujari H, Maunu J, Parkkola R, Rikalainen H, Lapinleimu H, Lehtonen L, Haataja L; PIPARI Study Group. Does placental inflammation relate to brain lesions and volume in preterm infants? J Pediatr. 2008 May;152(5):642-7, 647.e1-2. doi: 10.1016/j.jpeds.2007.09.051. Epub 2007 Dec 21.

PUBMED 18410766
Additional Publications
  • Nyman A, Korhonen T, Munck P, Parkkola R, Lehtonen L, Haataja L. Factors affecting the cognitive profile of 11-year-old children born very preterm. Pediatr Res. 2017 Aug;82(2):324-332. doi: 10.1038/pr.2017.64. Epub 2017 May 24. PMID: 28422947.


PIPARI cohort

Selection Criteria
  • Finland
Geographical Area
Southwest Finland
VPT/VLBW Group Inclusion Criteria
Infants born in Turku university hospital between January 2001 and December 2006. Inclusion criteria were 1) infant’s birth weight ≤1500 grams (VLBW), and after April 2004, infant’s birth weight ≤1500 grams or gestational age below 32 weeks (VPT), 2) infant’s parents spoke and understood written Finnish or Swedish, and 3) families lived inside the hospital catchment area.
Control Group Inclusion Criteria
Full term infants born in Turku university hospital between 11/2001 to 12/2003. The parents of first boy and girl born in each week was asked to take part in the study. If they refused, the parents of next boy/girl were asked. Inclusion criteria were 1) birth weight ≥-2 SD according to age and gender specific Finnish growth charts 2) gestational age ≥37 weeks at birth 3) the family lived inside the hospital catchment area 4) the child was not admitted to neonatal care during the first week of life 5) family was Finnish or Swedish speaking.
VPT/VLBW Group Exclusion Criteria
Infants with major congenital anomalies or syndromes or chromosomal anomalies were excluded.
Control Group Exclusion Criteria
1) congenital anomalies or syndromes 2) mothers self-reported use of illicit drugs or alcohol during the pregnancy.
Supplementary Information
Controls were recruited right after birth before discharge from maternity ward in the beginning of the data collection period. Same group was used at each age.
Data Collection Events
# Name Description Start End
0 Perinatal Assessment 2001-01 2006-12
1 6 Month Follow Up 2001 2007
2 1 Year Follow Up 2002 2007
3 2 Year Follow Up 2003 2008
4 3 Year Follow Up 2004 2009
5 4 Year Follow Up 2005 2010
6 5 Year Follow Up 2006 2011
7 7 Year Follow Up 2008 2013
8 11 Year Follow Up 2012 2017
9 13 Year Follow Up 2014 2019