PIPARI Perinatal Dataset
|Development and Functioning of Very Low Birth Weight Infants from Infancy to School Age
|Number of very preterm (VPT) and/or very low birthweight (VLBW) births included in cohort (live & still births)
|Number of term-born control births included in cohort (live & still births)
PIPARI is a regional cohort consisting of infants born in Turku University Hospital between 2001 and 2006 at very low birth weight or very preterm.
Data Collection Event
Perinatal data were collected prospectively as part of the PIPARI protocol. Data were collected on maternal characteristics, pregnancy, delivery, neonatal characteristics and early mortality. Items were also collected on neonatal treatment. Brain ultrasound, brain MRI and Brainstem Auditory Evoked Potentials (BAEP) were carried out for the preterm infants during the neonatal period. All surviving infants underwent a Dubowitz neurological examination performed by an experienced physician and physiotherapist at 36 weeks of gestational age, term age, and at one and two months corrected age. Antenatal Doppler of blood flow in the umbilical artery (UA), fetal middle cerebral artery (MCA), descending aorta (DAo), aortic isthmus, and ductus venosus were carried out on a subset of the cohort. Placental samples taken for histological analyses of chorioamnionitis and DNA samples for the analyses of IL-6 –572, IL-174 and Apolipoprotein E genotypes were obtained for preterm infants.